Borderline and malignant serous tumor arising in pelvic lymph nodes: evidence of origin in benign glandular inclusions.

Journal Article (Journal Article)

This report describes two cases of malignant serous cancers with areas of borderline malignancy, which appear to have arisen within benign glandular inclusions of coelomic origin in pelvic or para-aortic lymph nodes. The patients were 44 and 62 years of age. In both cases the nodes contained benign glandular inclusions lined by a single layer of epithelium which resembled that of tubal epithelium. The location of the glandular epithelium varied from within the fat near the node to intracapsular, subcapsular, or interfollicular positions. The number of glands ranged from few to extensive. In both cases the glandular inclusions disclosed epithelial proliferations, ranging from minor degrees of stratification with formation of small papillae of atypical cells (borderline serous tumor) to almost solid tumor typical of serous cancer. In both cases, the borderline and cancerous tumors exhibited areas of transition which appeared to arise from benign glands. Although benign glandular inclusions of coelomic origin are well documented to occur in pelvic or para-aortic lymph nodes of 5-20% of women and have been considered to be of significance only because of the possibility of the misdiagnosis of cancer, it should now be recognized that the glandular inclusion cysts themselves can become neoplastic.

Full Text

Duke Authors

Cited Authors

  • Prade, M; Spatz, A; Bentley, R; Duvillard, P; Bognel, C; Robboy, SJ

Published Date

  • January 1995

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 87 - 91

PubMed ID

  • 7883433

International Standard Serial Number (ISSN)

  • 0277-1691

Digital Object Identifier (DOI)

  • 10.1097/00004347-199501000-00015


  • eng

Conference Location

  • United States