Endometrial cancer: stage at diagnosis and associated factors in black and white patients.

Journal Article (Journal Article)

OBJECTIVE: This study examined the relationship of clinicopathologic, health status, medical system, and socioeconomic factors to differences in stage at diagnosis of endometrial cancer in black and white patients. STUDY DESIGN: A population-based study of 130 black and 329 white patients with invasive endometrial cancer was conducted as part of the National Cancer Institute's Black/White Cancer Survival Study. Logistic regression was used to determine the relative importance of factors thought to be related to stage at diagnosis after age and geographic location were adjusted for. RESULTS: High-grade (poorly differentiated) lesions increased the risk for stage III or IV disease (odds ratio 8.3, 95% confidence interval 3.4 to 20.3), as did serous histologic subtype (odds ratio 3.5, 95% confidence interval 1.4 to 8.8) and no usual source of care (odds ratio 5.5, 95% confidence interval 1.4 to 20.9). In the final statistical model these three factors also accounted for the majority of the excess risk of advanced stage for blacks. CONCLUSIONS: Black-white racial disparities in stage at diagnosis appear to be related to higher-grade lesions and more aggressive histologic subtypes occurring more frequently in black patients with endometrial cancer.

Full Text

Duke Authors

Cited Authors

  • Barrett, RJ; Harlan, LC; Wesley, MN; Hill, HA; Chen, VW; Clayton, LA; Kotz, HL; Eley, JW; Robboy, SJ; Edwards, BK

Published Date

  • August 1995

Published In

Volume / Issue

  • 173 / 2

Start / End Page

  • 414 - 422

PubMed ID

  • 7645616

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/0002-9378(95)90261-9


  • eng

Conference Location

  • United States