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Placental site trophoblastic tumor arising from antecedent molar pregnancy.

Publication ,  Journal Article
Moore-Maxwell, CA; Robboy, SJ
Published in: Gynecol Oncol
February 2004

OBJECTIVE: Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic disease. Little is known about its pathogenesis and natural history. METHODS: This report describes two cases that arose in patients with documented complete hydatidiform moles and summarizes the antecedent prenatal histories of PSTTs based on a detailed Medline literature analysis. CASES: A 28-year-old, G(2)P(2) female had a live, 12-week gestation fetus and a coexisting molar pregnancy. Her hCG levels dropped promptly from 1.5 million to 23,273 IU/ml after termination, but rose shortly thereafter together with the onset of recurrent vaginal bleeding. Curettage revealed persistent mole. Persistently elevated hCG led to hysterectomy disclosing a fundal PSTT. The second case was that of a 48-year-old, G(2) woman who presented with symptoms of preeclampsia, hyperthyroidism, and elevated hCG. Curettage yielded a complete hydatidiform mole. Although the hCG level decreased for a short period, it soon increased despite treatment with methotrexate. A second curettage revealed a PSTT. DISCUSSION: A Medline literature analysis of PSTT, which consists almost entirely of individual cases and several small series, disclosed that PSTT is preceded in 61% of cases by normal term pregnancy, 12% molar pregnancy, 9% spontaneous abortion, 8% therapeutic abortion, and 3% with ectopic pregnancy, stillbirths or preterm delivery. No information is known in 7%. This report describes two additional cases of PSTT preceded by complete molar pregnancy. CONCLUSIONS: PSTT is a well recognized, but uncommon form of gestational trophoblastic disease. Although little is known about its pathogenesis, it is preceded not uncommonly by an abnormal pregnancy, including a molar pregnancy.

Duke Scholars

Published In

Gynecol Oncol

DOI

ISSN

0090-8258

Publication Date

February 2004

Volume

92

Issue

2

Start / End Page

708 / 712

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Trophoblastic Tumor, Placental Site
  • Pregnancy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Hydatidiform Mole
  • Humans
  • Female
  • Adult
  • 3215 Reproductive medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moore-Maxwell, C. A., & Robboy, S. J. (2004). Placental site trophoblastic tumor arising from antecedent molar pregnancy. Gynecol Oncol, 92(2), 708–712. https://doi.org/10.1016/j.ygyno.2003.10.048
Moore-Maxwell, Crystal A., and Stanley J. Robboy. “Placental site trophoblastic tumor arising from antecedent molar pregnancy.Gynecol Oncol 92, no. 2 (February 2004): 708–12. https://doi.org/10.1016/j.ygyno.2003.10.048.
Moore-Maxwell CA, Robboy SJ. Placental site trophoblastic tumor arising from antecedent molar pregnancy. Gynecol Oncol. 2004 Feb;92(2):708–12.
Moore-Maxwell, Crystal A., and Stanley J. Robboy. “Placental site trophoblastic tumor arising from antecedent molar pregnancy.Gynecol Oncol, vol. 92, no. 2, Feb. 2004, pp. 708–12. Pubmed, doi:10.1016/j.ygyno.2003.10.048.
Moore-Maxwell CA, Robboy SJ. Placental site trophoblastic tumor arising from antecedent molar pregnancy. Gynecol Oncol. 2004 Feb;92(2):708–712.
Journal cover image

Published In

Gynecol Oncol

DOI

ISSN

0090-8258

Publication Date

February 2004

Volume

92

Issue

2

Start / End Page

708 / 712

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Trophoblastic Tumor, Placental Site
  • Pregnancy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Hydatidiform Mole
  • Humans
  • Female
  • Adult
  • 3215 Reproductive medicine