Mucinous adenocarcinoma arising in rectovaginal fistulas associated with Crohn's disease.
Journal Article (Journal Article)
BACKGROUND: Crohn's disease is a chronic inflammatory disorder characterized by focal, transmural inflammation of the intestine. Gynecologic involvement, including rectovaginal fistula formation, is frequent. Case #1. A 53-year-old female with a 30-year history of Crohn's disease and numerous perirectal fistulas developed a foul smelling, purulent drainage from her rectum and a mucopurulent, bloody discharge from her vagina. A lower vaginal lesion biopsy demonstrated a low-grade mucinous adenocarcinoma. Case #2. A 42-year-old female with a 15-year history of Crohn's disease developed drainage from her vagina. Physical examination revealed an enlarging mass involving the posterior wall of the vaginal vault that connected to the anus by a fistula tract. A biopsy revealed mucinous adenocarcinoma. CONCLUSIONS: Malignant transformation of persistent rectovaginal fistulas is a potential complication of Crohn's disease.
Full Text
Duke Authors
Cited Authors
- Moore-Maxwell, CA; Robboy, SJ
Published Date
- April 2004
Published In
Volume / Issue
- 93 / 1
Start / End Page
- 266 - 268
PubMed ID
- 15047250
International Standard Serial Number (ISSN)
- 0090-8258
Digital Object Identifier (DOI)
- 10.1016/j.ygyno.2003.11.056
Language
- eng
Conference Location
- United States