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An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases.

Publication ,  Journal Article
Snyder, MJ; Robboy, SJ; Vollmer, RT; Dodd, LG
Published in: Am J Clin Pathol
September 2004

Carcinosarcoma of the uterus has been poorly characterized on cervicovaginal (Pap) smears, and we examine whether they effectively screen for carcinosarcoma and whether an abnormal Pap smear result has any clinical importance. Twenty-five patients with histologically confirmed carcinosarcoma had a conventional Pap smear shortly before diagnosis. Eleven smears (44%) originally were read as abnormal (malignant or atypical), and 4 additional cases were read as abnormal on retrospective review (15/25 [60%]). All malignant elements were epithelial, and 2 cases (8%) had atypical spindle cells, but no diagnostic sarcoma. Cervical involvement was the only histologic parameter correlating with an abnormal Pap smear result (P = .04). Univariate analysis found stage III or IV disease was an adverse prognostic sign compared with stage I or II disease (mean survival, 8 vs 36 months, respectively; P = .001), and multivariate analysis indicated that an abnormal Pap smear result correlated with worse survival (P = .023). The conventional Pap smear is insensitive (60%) for detecting carcinosarcoma, but when the result is abnormal, the Pap is an important stage-independent adverse prognosticator.

Duke Scholars

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

September 2004

Volume

122

Issue

3

Start / End Page

434 / 439

Location

England

Related Subject Headings

  • Vaginal Smears
  • Uterine Neoplasms
  • Sensitivity and Specificity
  • Prognosis
  • Pathology
  • Papanicolaou Test
  • Mass Screening
  • Humans
  • Female
  • False Negative Reactions
 

Citation

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Chicago
ICMJE
MLA
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Snyder, M. J., Robboy, S. J., Vollmer, R. T., & Dodd, L. G. (2004). An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases. Am J Clin Pathol, 122(3), 434–439. https://doi.org/10.1309/KUA1-FQ3B-QRC8-YG4V
Snyder, Matthew J., Stanley J. Robboy, Robin T. Vollmer, and Leslie G. Dodd. “An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases.Am J Clin Pathol 122, no. 3 (September 2004): 434–39. https://doi.org/10.1309/KUA1-FQ3B-QRC8-YG4V.
Snyder MJ, Robboy SJ, Vollmer RT, Dodd LG. An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases. Am J Clin Pathol. 2004 Sep;122(3):434–9.
Snyder, Matthew J., et al. “An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases.Am J Clin Pathol, vol. 122, no. 3, Sept. 2004, pp. 434–39. Pubmed, doi:10.1309/KUA1-FQ3B-QRC8-YG4V.
Snyder MJ, Robboy SJ, Vollmer RT, Dodd LG. An abnormal cervicovaginal cytology smear in uterine carcinosarcoma is an adverse prognostic sign: analysis of 25 cases. Am J Clin Pathol. 2004 Sep;122(3):434–439.
Journal cover image

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

September 2004

Volume

122

Issue

3

Start / End Page

434 / 439

Location

England

Related Subject Headings

  • Vaginal Smears
  • Uterine Neoplasms
  • Sensitivity and Specificity
  • Prognosis
  • Pathology
  • Papanicolaou Test
  • Mass Screening
  • Humans
  • Female
  • False Negative Reactions