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Neoplasms and pathology of sexual developmental disorders (intersex).

Publication ,  Journal Article
Robboy, SJ; Jaubert, F
Published in: Pathology
February 2007

Continuing new insights into the biology of sexual development and advances in chromosome analysis have led to early identification and prompt treatment of the intersexual patient, the results of which facilitate a more normal life for affected individuals. Based on these advances, a classification of abnormal sexual development has been developed and refined that correlates the gonadal and genital anatomy with the chromosomal findings and specific genetic or metabolic defects. In a shift from a classification anchored on whether the intersex revolves about a specific gene or whole chromosomal abnormality, the current classification is organised by broader categories into which the intersexual disorders are divided into 'abnormalities of genital differentiation', due largely to the abnormal production or sensitivity of a single hormone, or 'abnormalities in sex determination', due to abnormal gonadal differentiation, usually testicular, with or without chromosomal aberration. The current classification is an integrated approach to this complex group of disorders and is organised according to the manner by which patients present as well as on the pathophysiological basis of the defect. The classification also groups patients who are at high risk for development of gonadal neoplasia.

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Published In

Pathology

DOI

ISSN

0031-3025

Publication Date

February 2007

Volume

39

Issue

1

Start / End Page

147 / 163

Location

England

Related Subject Headings

  • Pathology
  • Neoplasms, Germ Cell and Embryonal
  • Male
  • Humans
  • Female
  • Disorders of Sex Development
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Robboy, S. J., & Jaubert, F. (2007). Neoplasms and pathology of sexual developmental disorders (intersex). Pathology, 39(1), 147–163. https://doi.org/10.1080/00313020601137359
Robboy, Stanley J., and Francis Jaubert. “Neoplasms and pathology of sexual developmental disorders (intersex).Pathology 39, no. 1 (February 2007): 147–63. https://doi.org/10.1080/00313020601137359.
Robboy SJ, Jaubert F. Neoplasms and pathology of sexual developmental disorders (intersex). Pathology. 2007 Feb;39(1):147–63.
Robboy, Stanley J., and Francis Jaubert. “Neoplasms and pathology of sexual developmental disorders (intersex).Pathology, vol. 39, no. 1, Feb. 2007, pp. 147–63. Pubmed, doi:10.1080/00313020601137359.
Robboy SJ, Jaubert F. Neoplasms and pathology of sexual developmental disorders (intersex). Pathology. 2007 Feb;39(1):147–163.
Journal cover image

Published In

Pathology

DOI

ISSN

0031-3025

Publication Date

February 2007

Volume

39

Issue

1

Start / End Page

147 / 163

Location

England

Related Subject Headings

  • Pathology
  • Neoplasms, Germ Cell and Embryonal
  • Male
  • Humans
  • Female
  • Disorders of Sex Development
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences