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Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers.

Publication ,  Journal Article
Baak, JPA; Kruse, A-J; Robboy, SJ; Janssen, EAM; van Diermen, B; Skaland, I
Published in: J Clin Pathol
October 2006

The microscopic phenotype of cervical intraepithelial neoplasia (CIN) reflects a fine balance between factors that promote or reduce CIN development. A shortcoming of the current grading system is its reliance on static morphology and microscopic haematoxylin-eosin features of the epithelium alone. In reality, CIN is a dynamic process, and the epithelium may exhibit differing results over time. Functional biomarkers p16, Ki-67, p53, retinoblastoma protein cytokeratin (CK)14 and CK13, help in the assessment of an individual CIN's lesion's potential for progression and regression. The aggregate information provided by these biomarkers exceeds the value of the classic grading system. Consequently, many more CINs that will either regress or progress can be accurately identified. These findings agree with known molecular interactions between HPV and the host. For accurate interpretation of a CIN, it is essential that these biomarkers be determined quantitatively and separately in the superficial, middle and deep layers of the epithelium. Such geography-specific epithelial evaluations of quantitative biomarkers emphasise the dynamic nature of a particular CIN lesion, thereby changing the art of static morphology grading into dynamic interpretation of the diseased tissue, with a strong prognostic effect.

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Published In

J Clin Pathol

DOI

ISSN

0021-9746

Publication Date

October 2006

Volume

59

Issue

10

Start / End Page

1017 / 1028

Location

England

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Pathology
  • Papillomavirus Infections
  • Ki-67 Antigen
  • Humans
  • Female
  • Disease Progression
  • Cyclin-Dependent Kinase Inhibitor p16
  • Biomarkers, Tumor
 

Citation

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Baak, J. P. A., Kruse, A.-J., Robboy, S. J., Janssen, E. A. M., van Diermen, B., & Skaland, I. (2006). Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers. J Clin Pathol, 59(10), 1017–1028. https://doi.org/10.1136/jcp.2005.027839
Baak, J. P. A., A. -. J. Kruse, S. J. Robboy, E. A. M. Janssen, B. van Diermen, and I. Skaland. “Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers.J Clin Pathol 59, no. 10 (October 2006): 1017–28. https://doi.org/10.1136/jcp.2005.027839.
Baak JPA, Kruse A-J, Robboy SJ, Janssen EAM, van Diermen B, Skaland I. Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers. J Clin Pathol. 2006 Oct;59(10):1017–28.
Baak, J. P. A., et al. “Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers.J Clin Pathol, vol. 59, no. 10, Oct. 2006, pp. 1017–28. Pubmed, doi:10.1136/jcp.2005.027839.
Baak JPA, Kruse A-J, Robboy SJ, Janssen EAM, van Diermen B, Skaland I. Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers. J Clin Pathol. 2006 Oct;59(10):1017–1028.

Published In

J Clin Pathol

DOI

ISSN

0021-9746

Publication Date

October 2006

Volume

59

Issue

10

Start / End Page

1017 / 1028

Location

England

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Pathology
  • Papillomavirus Infections
  • Ki-67 Antigen
  • Humans
  • Female
  • Disease Progression
  • Cyclin-Dependent Kinase Inhibitor p16
  • Biomarkers, Tumor