Reduced kainic acid binding in rat hippocampal formation after limbic kindling.

Journal Article (Journal Article)

The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less than in electrode-implanted unstimulated controls. Specific binding in the inner third of the dentate molecular layer was reduced to a lesser degree. These observations demonstrate that kainic acid receptors are down-regulated by kindling stimulation.

Full Text

Duke Authors

Cited Authors

  • Savage, DD; Nadler, JV; McNamara, JO

Published Date

  • December 3, 1984

Published In

Volume / Issue

  • 323 / 1

Start / End Page

  • 128 - 131

PubMed ID

  • 6098330

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(84)90274-9


  • eng

Conference Location

  • Netherlands