Sodium-dependent proline and glutamate uptake by hippocampal synaptosomes during postnatal development.

Journal Article (Journal Article)

NA(+)-dependent uptake of proline and glutamate by hippocampal synaptosomes was studied during postnatal development. At all ages from 9 days to adulthood, hippocampal synaptosomes transported proline by both a high-affinity and a low-affinity process, whereas glutamate was always transported predominantly by a high-affinity process. During the period of rapid synaptogenesis, the KT for high-affinity proline transport overshot the adult value, whereas the KT for glutamate transport increased steadily toward the adult value. The ratio of KT values for proline and glutamate was 2-3 times the adult value between 12 and 24 days of age. Although high-affinity transporters for proline and glutamate are expressed by nearly the same hippocampal pathways, they are differentially regulated during postnatal development.

Full Text

Duke Authors

Cited Authors

  • Cohen, SM; Nadler, JV

Published Date

  • June 18, 1997

Published In

Volume / Issue

  • 100 / 2

Start / End Page

  • 230 - 233

PubMed ID

  • 9205813

International Standard Serial Number (ISSN)

  • 0165-3806

Digital Object Identifier (DOI)

  • 10.1016/s0165-3806(97)00045-x


  • eng

Conference Location

  • Netherlands