Sodium-dependent proline and glutamate uptake by hippocampal synaptosomes during postnatal development.
Journal Article (Journal Article)
NA(+)-dependent uptake of proline and glutamate by hippocampal synaptosomes was studied during postnatal development. At all ages from 9 days to adulthood, hippocampal synaptosomes transported proline by both a high-affinity and a low-affinity process, whereas glutamate was always transported predominantly by a high-affinity process. During the period of rapid synaptogenesis, the KT for high-affinity proline transport overshot the adult value, whereas the KT for glutamate transport increased steadily toward the adult value. The ratio of KT values for proline and glutamate was 2-3 times the adult value between 12 and 24 days of age. Although high-affinity transporters for proline and glutamate are expressed by nearly the same hippocampal pathways, they are differentially regulated during postnatal development.
Full Text
Duke Authors
Cited Authors
- Cohen, SM; Nadler, JV
Published Date
- June 18, 1997
Published In
Volume / Issue
- 100 / 2
Start / End Page
- 230 - 233
PubMed ID
- 9205813
International Standard Serial Number (ISSN)
- 0165-3806
Digital Object Identifier (DOI)
- 10.1016/s0165-3806(97)00045-x
Language
- eng
Conference Location
- Netherlands