Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses.
Publication
, Journal Article
Molnár, P; Nadler, JV
Published in: Brain Res
August 10, 2001
Hippocampal slices from pilocarpine-treated rats were used to explore the effect of zinc released at mossy fiber synapses on dentate granule cells. Chelation of zinc enhanced the N-methyl-D-aspartate (NMDA) receptor-mediated component of the excitatory postsynaptic current (EPSC), but did not affect the AMPA/kainate receptor-mediated component. Its effect was detectable only at negative membrane potentials and was pathway specific. Thus corelease of zinc reduces the ability of glutamate to activate postsynaptic NMDA receptors. Through this action, zinc would be expected to attenuate granule cell epileptiform activity supported by the recurrent mossy fiber pathway.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
August 10, 2001
Volume
910
Issue
1-2
Start / End Page
205 / 207
Location
Netherlands
Related Subject Headings
- Zinc
- Synaptic Transmission
- Synapses
- Receptors, N-Methyl-D-Aspartate
- Rats
- Pilocarpine
- Patch-Clamp Techniques
- Neurology & Neurosurgery
- Muscarinic Agonists
- Mossy Fibers, Hippocampal
Citation
APA
Chicago
ICMJE
MLA
NLM
Molnár, P., & Nadler, J. V. (2001). Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. Brain Res, 910(1–2), 205–207. https://doi.org/10.1016/s0006-8993(01)02720-2
Molnár, P., and J. V. Nadler. “Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses.” Brain Res 910, no. 1–2 (August 10, 2001): 205–7. https://doi.org/10.1016/s0006-8993(01)02720-2.
Molnár P, Nadler JV. Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. Brain Res. 2001 Aug 10;910(1–2):205–7.
Molnár, P., and J. V. Nadler. “Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses.” Brain Res, vol. 910, no. 1–2, Aug. 2001, pp. 205–07. Pubmed, doi:10.1016/s0006-8993(01)02720-2.
Molnár P, Nadler JV. Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. Brain Res. 2001 Aug 10;910(1–2):205–207.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
August 10, 2001
Volume
910
Issue
1-2
Start / End Page
205 / 207
Location
Netherlands
Related Subject Headings
- Zinc
- Synaptic Transmission
- Synapses
- Receptors, N-Methyl-D-Aspartate
- Rats
- Pilocarpine
- Patch-Clamp Techniques
- Neurology & Neurosurgery
- Muscarinic Agonists
- Mossy Fibers, Hippocampal