Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses.
Journal Article (Journal Article)
Hippocampal slices from pilocarpine-treated rats were used to explore the effect of zinc released at mossy fiber synapses on dentate granule cells. Chelation of zinc enhanced the N-methyl-D-aspartate (NMDA) receptor-mediated component of the excitatory postsynaptic current (EPSC), but did not affect the AMPA/kainate receptor-mediated component. Its effect was detectable only at negative membrane potentials and was pathway specific. Thus corelease of zinc reduces the ability of glutamate to activate postsynaptic NMDA receptors. Through this action, zinc would be expected to attenuate granule cell epileptiform activity supported by the recurrent mossy fiber pathway.
Full Text
Duke Authors
Cited Authors
- Molnár, P; Nadler, JV
Published Date
- August 10, 2001
Published In
Volume / Issue
- 910 / 1-2
Start / End Page
- 205 - 207
PubMed ID
- 11489274
International Standard Serial Number (ISSN)
- 0006-8993
Digital Object Identifier (DOI)
- 10.1016/s0006-8993(01)02720-2
Language
- eng
Conference Location
- Netherlands