Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.


Journal Article

Intracerebroventricular kainic acid produces in rats brain lesions similar to Ammon's horn sclerosis in humans. To test the hypothesis that these lesions result indirectly from prolonged seizure activity and not from a direct action of kainic acid on the neurons that are destroyed, the effects of intracerebroventricular kainic acid and bicuculline methiodide were compared. Although bicuculline methiodide seizures differed dramatically from kainic acid seizures, both electrographically and behaviorally, the resulting brain lesions were similar for a given total limbic seizure duration. These results, in combination with other data, support the view that lesions made by intracerebroventricular administration of convulsants are indeed caused by prolonged limbic seizures. The total duration of seizure activity appears to be one important variable.

Full Text

Duke Authors

Cited Authors

  • Gruenthal, M; Armstrong, DR; Ault, B; Nadler, JV

Published Date

  • September 1986

Published In

Volume / Issue

  • 93 / 3

Start / End Page

  • 621 - 630

PubMed ID

  • 3743707

Pubmed Central ID

  • 3743707

International Standard Serial Number (ISSN)

  • 0014-4886

Digital Object Identifier (DOI)

  • 10.1016/0014-4886(86)90181-0


  • eng

Conference Location

  • United States