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The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.

Publication ,  Journal Article
Martin, D; Thompson, MA; Nadler, JV
Published in: Eur J Pharmacol
December 21, 1993

Riluzole is believed to exert its anticonvulsant and neuroprotective actions by reducing glutamate release. This study demonstrated that 10-30 microM riluzole reduces the K(+)-evoked release of glutamate and aspartate from slices of hippocampal area CA1. Only higher concentrations reduced gamma-aminobutyrate (GABA) release. These actions of riluzole were not occluded by tetrodotoxin. Riluzole did not diminish the ability of glutamate analogues to depolarize CA1 pyramidal cells, as determined from grease-gap recordings. Therefore the anticonvulsant and neuroprotective actions of riluzole in the hippocampus may be at least partly explained by its ability to inhibit glutamate/aspartate release from synaptic terminals.

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Published In

Eur J Pharmacol

DOI

ISSN

0014-2999

Publication Date

December 21, 1993

Volume

250

Issue

3

Start / End Page

473 / 476

Location

Netherlands

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Thiazoles
  • Riluzole
  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Cells
  • Potassium
  • Pharmacology & Pharmacy
  • Hippocampus
  • Glutamates
 

Citation

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Martin, D., Thompson, M. A., & Nadler, J. V. (1993). The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol, 250(3), 473–476. https://doi.org/10.1016/0014-2999(93)90037-i
Martin, D., M. A. Thompson, and J. V. Nadler. “The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.Eur J Pharmacol 250, no. 3 (December 21, 1993): 473–76. https://doi.org/10.1016/0014-2999(93)90037-i.
Martin D, Thompson MA, Nadler JV. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol. 1993 Dec 21;250(3):473–6.
Martin, D., et al. “The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.Eur J Pharmacol, vol. 250, no. 3, Dec. 1993, pp. 473–76. Pubmed, doi:10.1016/0014-2999(93)90037-i.
Martin D, Thompson MA, Nadler JV. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol. 1993 Dec 21;250(3):473–476.
Journal cover image

Published In

Eur J Pharmacol

DOI

ISSN

0014-2999

Publication Date

December 21, 1993

Volume

250

Issue

3

Start / End Page

473 / 476

Location

Netherlands

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Thiazoles
  • Riluzole
  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Cells
  • Potassium
  • Pharmacology & Pharmacy
  • Hippocampus
  • Glutamates