The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.
Publication
, Journal Article
Martin, D; Thompson, MA; Nadler, JV
Published in: Eur J Pharmacol
December 21, 1993
Riluzole is believed to exert its anticonvulsant and neuroprotective actions by reducing glutamate release. This study demonstrated that 10-30 microM riluzole reduces the K(+)-evoked release of glutamate and aspartate from slices of hippocampal area CA1. Only higher concentrations reduced gamma-aminobutyrate (GABA) release. These actions of riluzole were not occluded by tetrodotoxin. Riluzole did not diminish the ability of glutamate analogues to depolarize CA1 pyramidal cells, as determined from grease-gap recordings. Therefore the anticonvulsant and neuroprotective actions of riluzole in the hippocampus may be at least partly explained by its ability to inhibit glutamate/aspartate release from synaptic terminals.
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Published In
Eur J Pharmacol
DOI
ISSN
0014-2999
Publication Date
December 21, 1993
Volume
250
Issue
3
Start / End Page
473 / 476
Location
Netherlands
Related Subject Headings
- gamma-Aminobutyric Acid
- Thiazoles
- Riluzole
- Rats, Sprague-Dawley
- Rats
- Pyramidal Cells
- Potassium
- Pharmacology & Pharmacy
- Hippocampus
- Glutamates
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Martin, D., Thompson, M. A., & Nadler, J. V. (1993). The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol, 250(3), 473–476. https://doi.org/10.1016/0014-2999(93)90037-i
Martin, D., M. A. Thompson, and J. V. Nadler. “The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.” Eur J Pharmacol 250, no. 3 (December 21, 1993): 473–76. https://doi.org/10.1016/0014-2999(93)90037-i.
Martin D, Thompson MA, Nadler JV. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol. 1993 Dec 21;250(3):473–6.
Martin, D., et al. “The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.” Eur J Pharmacol, vol. 250, no. 3, Dec. 1993, pp. 473–76. Pubmed, doi:10.1016/0014-2999(93)90037-i.
Martin D, Thompson MA, Nadler JV. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol. 1993 Dec 21;250(3):473–476.
Published In
Eur J Pharmacol
DOI
ISSN
0014-2999
Publication Date
December 21, 1993
Volume
250
Issue
3
Start / End Page
473 / 476
Location
Netherlands
Related Subject Headings
- gamma-Aminobutyric Acid
- Thiazoles
- Riluzole
- Rats, Sprague-Dawley
- Rats
- Pyramidal Cells
- Potassium
- Pharmacology & Pharmacy
- Hippocampus
- Glutamates