Toxicity of L-proline toward rat hippocampal neurons.

Journal Article (Journal Article)

Intrahippocampal injections of L-proline, a neutral amino acid excitant, non-selectively destroyed pyramidal and granule cells. Co-administration of equimolar kynurenate, an excitatory amino acid antagonist, markedly reduced the extent of neuronal cell death. L-Proline destroyed far more hippocampal neurons than D-proline, in keeping with its greater neuroexcitatory potency. L-Proline must therefore be added to the list of excitotoxins present in brain. Its excitotoxic action may be related to the neurological and cognitive deficits associated with hyperprolinemia.

Full Text

Duke Authors

Cited Authors

  • Nadler, JV; Wang, A; Hakim, A

Published Date

  • July 19, 1988

Published In

Volume / Issue

  • 456 / 1

Start / End Page

  • 168 - 172

PubMed ID

  • 3409032

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(88)90358-7


  • eng

Conference Location

  • Netherlands