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Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome.

Publication ,  Journal Article
Ault, B; Gruenthal, M; Armstrong, DR; Nadler, JV
Published in: J Pharmacol Exp Ther
November 1986

Baclofen and phenobarbital were tested for anticonvulsant efficacy against limbic seizures produced by i.c.v. infusion of kainic acid (KA) in unanesthetized rats. All rats treated with KA alone developed a prolonged status epilepticus associated with extensive neuronal degeneration. When administered immediately after the KA infusion, baclofen (5 mg/kg i.p.) protected five of six animals against the development of status epilepticus and did not alter the behavioral expression of the residual discrete electrographic seizures. Phenobarbital (40 mg/kg i.p.) given 15 min before KA also prevented the development of status epilepticus in five of six rats, but blocked the behavioral expression of the residual electrographic seizures. In two of five additional rats, baclofen prevented or reversed status epilepticus when administered 50 to 60 min after the end of the KA infusion. The ability of these drugs to prevent KA-induced neuronal degeneration correlated with their anticonvulsant action.

Duke Scholars

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

November 1986

Volume

239

Issue

2

Start / End Page

612 / 617

Location

United States

Related Subject Headings

  • Time Factors
  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Phenobarbital
  • Pharmacology & Pharmacy
  • Male
  • Limbic System
  • Kainic Acid
  • Injections, Intraventricular
 

Citation

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Ault, B., Gruenthal, M., Armstrong, D. R., & Nadler, J. V. (1986). Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome. J Pharmacol Exp Ther, 239(2), 612–617.
Ault, B., M. Gruenthal, D. R. Armstrong, and J. V. Nadler. “Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome.J Pharmacol Exp Ther 239, no. 2 (November 1986): 612–17.
Ault B, Gruenthal M, Armstrong DR, Nadler JV. Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome. J Pharmacol Exp Ther. 1986 Nov;239(2):612–7.
Ault, B., et al. “Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome.J Pharmacol Exp Ther, vol. 239, no. 2, Nov. 1986, pp. 612–17.
Ault B, Gruenthal M, Armstrong DR, Nadler JV. Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome. J Pharmacol Exp Ther. 1986 Nov;239(2):612–617.

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

November 1986

Volume

239

Issue

2

Start / End Page

612 / 617

Location

United States

Related Subject Headings

  • Time Factors
  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Phenobarbital
  • Pharmacology & Pharmacy
  • Male
  • Limbic System
  • Kainic Acid
  • Injections, Intraventricular