Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome.

Journal Article (Journal Article)

Baclofen and phenobarbital were tested for anticonvulsant efficacy against limbic seizures produced by i.c.v. infusion of kainic acid (KA) in unanesthetized rats. All rats treated with KA alone developed a prolonged status epilepticus associated with extensive neuronal degeneration. When administered immediately after the KA infusion, baclofen (5 mg/kg i.p.) protected five of six animals against the development of status epilepticus and did not alter the behavioral expression of the residual discrete electrographic seizures. Phenobarbital (40 mg/kg i.p.) given 15 min before KA also prevented the development of status epilepticus in five of six rats, but blocked the behavioral expression of the residual electrographic seizures. In two of five additional rats, baclofen prevented or reversed status epilepticus when administered 50 to 60 min after the end of the KA infusion. The ability of these drugs to prevent KA-induced neuronal degeneration correlated with their anticonvulsant action.

Full Text

Duke Authors

Cited Authors

  • Ault, B; Gruenthal, M; Armstrong, DR; Nadler, JV

Published Date

  • November 1986

Published In

Volume / Issue

  • 239 / 2

Start / End Page

  • 612 - 617

PubMed ID

  • 3772812

International Standard Serial Number (ISSN)

  • 0022-3565


  • eng

Conference Location

  • United States