Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion.
Journal Article (Journal Article)
Destruction of the hippocampal perforant path fibers reduced the binding of [3H]GABA to membranes prepared from the rat fascia dentata. This result could be detected 1--4 months after surgery, but not in 10 days or less. Such a delayed response appears most compatible with a transsynaptic effect on GABA receptors. Values of low affinity KD and Bmax decreased by about 65%, but no changes were detected in high affinity binding, Hill slope or pharmacological specificity. These findings are consistent with a desensitization of postsynaptic low affinity GABA receptors, possible caused by excessive release of GABA.
Full Text
Duke Authors
Cited Authors
- Nadler, JV
Published Date
- November 4, 1981
Published In
Volume / Issue
- 26 / 3
Start / End Page
- 275 - 281
PubMed ID
- 6275317
International Standard Serial Number (ISSN)
- 0304-3940
Digital Object Identifier (DOI)
- 10.1016/0304-3940(81)90145-2
Language
- eng
Conference Location
- Ireland