Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion.

Journal Article

Destruction of the hippocampal perforant path fibers reduced the binding of [3H]GABA to membranes prepared from the rat fascia dentata. This result could be detected 1--4 months after surgery, but not in 10 days or less. Such a delayed response appears most compatible with a transsynaptic effect on GABA receptors. Values of low affinity KD and Bmax decreased by about 65%, but no changes were detected in high affinity binding, Hill slope or pharmacological specificity. These findings are consistent with a desensitization of postsynaptic low affinity GABA receptors, possible caused by excessive release of GABA.

Full Text

Duke Authors

Cited Authors

  • Nadler, JV

Published Date

  • November 4, 1981

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 275 - 281

PubMed ID

  • 6275317

International Standard Serial Number (ISSN)

  • 0304-3940

Language

  • eng

Conference Location

  • Ireland