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A model of status epilepticus based on electrical stimulation of hippocampal afferent pathways.

Publication ,  Journal Article
Vicedomini, JP; Nadler, JV
Published in: Exp Neurol
June 1987

A new model of status epilepticus has been developed in the unanesthetized rat. The model involves repetitive tetanic stimulation of hippocampal afferent pathways. Pulse trains were delivered according to a fixed schedule (0.2 to 0.4-ms monophasic rectangular pulses, 20 Hz, stimulus current adjusted for maximal synaptic response in area CA3 of the hippocampus, 10-s train duration, 30-s intertrain interval) through electrodes chronically implanted in the angular bundle or fimbria. CA3 pyramidal cells responded to each stimulus in the train with little or no decrement. When 10 consecutive trains each produced 30 s of hippocampal afterdischarge, stimulation was terminated and self-sustained electrographic seizure activity was monitored. This procedure was repeated until it yielded at least 15 min of self-sustained seizure activity. Status epilepticus occurred in about 85% of subjects within less than 7 h. Self-sustained electrographic seizures were associated with limbic motor seizures and with brain lesions that resembled Ammon's horn sclerosis. This model holds promise for analyzing the biochemical and physiological bases of seizures, status epilepticus, and neuronal cell death, because the timing of these events during the stimulation protocol is fairly predictable and because seizures are self-sustaining without the need drugs, toxins, or prior kindling.

Duke Scholars

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

June 1987

Volume

96

Issue

3

Start / End Page

681 / 691

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Seizures
  • Rats
  • Neurology & Neurosurgery
  • Neural Pathways
  • Membrane Potentials
  • Male
  • Limbic System
  • Hippocampus
  • Electroencephalography
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Vicedomini, J. P., & Nadler, J. V. (1987). A model of status epilepticus based on electrical stimulation of hippocampal afferent pathways. Exp Neurol, 96(3), 681–691. https://doi.org/10.1016/0014-4886(87)90229-9
Vicedomini, J. P., and J. V. Nadler. “A model of status epilepticus based on electrical stimulation of hippocampal afferent pathways.Exp Neurol 96, no. 3 (June 1987): 681–91. https://doi.org/10.1016/0014-4886(87)90229-9.
Vicedomini, J. P., and J. V. Nadler. “A model of status epilepticus based on electrical stimulation of hippocampal afferent pathways.Exp Neurol, vol. 96, no. 3, June 1987, pp. 681–91. Pubmed, doi:10.1016/0014-4886(87)90229-9.
Vicedomini JP, Nadler JV. A model of status epilepticus based on electrical stimulation of hippocampal afferent pathways. Exp Neurol. 1987 Jun;96(3):681–691.
Journal cover image

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

June 1987

Volume

96

Issue

3

Start / End Page

681 / 691

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Seizures
  • Rats
  • Neurology & Neurosurgery
  • Neural Pathways
  • Membrane Potentials
  • Male
  • Limbic System
  • Hippocampus
  • Electroencephalography