High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype.

Published

Journal Article

Focal adhesion kinase (FAK) is a protein tyrosine kinase expressed in invasive breast cancer that regulates antiapoptotic signaling. We have examined FAK expression by immunohistochemistry using anti-FAK 4.47 in breast tumor samples from a large population-based, case-control study of women participating in the University of North Carolina Breast Specialized Programs of Research Excellence (SPORE), Carolina Breast Cancer Study. In this population, 629 formalin-fixed, paraffin-embedded tissue sections were stained for FAK and scored as high (3+ or 4+ intensity and > or = 90% positive cells) or otherwise. High FAK expression was associated with poor prognostic indicators including high mitotic index (>10 mitoses per 10 consecutive high-power fields), nuclear grade 3, architectural grade 3, estrogen and progesterone receptor negative, and HER-2/neu overexpressed using CB11 antibody. The association of high FAK expression with HER-2/neu overexpression lends further support that HER-2/neu and FAK collaborate to promote tumorigenesis. The presence of strong FAK expression in many high grade, estrogen- and progesterone-negative breast carcinomas indicates that FAK may be an attractive target for therapeutic intervention.

Full Text

Duke Authors

Cited Authors

  • Lark, AL; Livasy, CA; Dressler, L; Moore, DT; Millikan, RC; Geradts, J; Iacocca, M; Cowan, D; Little, D; Craven, RJ; Cance, W

Published Date

  • October 2005

Published In

Volume / Issue

  • 18 / 10

Start / End Page

  • 1289 - 1294

PubMed ID

  • 15861214

Pubmed Central ID

  • 15861214

Electronic International Standard Serial Number (EISSN)

  • 1530-0285

International Standard Serial Number (ISSN)

  • 0893-3952

Digital Object Identifier (DOI)

  • 10.1038/modpathol.3800424

Language

  • eng