Dose-intense cyclophosphamide and etoposide for patients with refractory or high-risk non-Hodgkin's lymphoma.

Journal Article (Journal Article)

A retrospective review was performed on the toxicity and response to one cycle of dose-intense cyclophosphamide/etoposide, followed by consolidation in patients with refractory or previously untreated, high-risk non-Hodgkin's lymphoma (NHL). Fifty-five patients with refractory NHL and 13 with untreated, high-risk NHL were administered one cycle of daily cyclophosphamide 1.5 g/m2 intravenously on days 1-4 and etoposide 300 mg/m2 intravenously every 12 hours on days 1-3. Responders then received other consolidated regimens. Twenty-seven percent of patients with refractory disease had moderate or severe stomatitis, and 44% had moderate or severe infections with 6 (11%) dying of this complication. Similar complication rates were noted in the previously untreated, high-risk group, but there was no treatment-related mortality. The overall response rate to this one cycle of therapy was 31% in the refractory group, with 18% complete response and 13% partial response. The overall response rate in the previously untreated, high-risk group was 69%, with 54% complete and 15% partial responses. In responders, the 2-year event-free survival was 27% in the refractory group and 56% in high-risk group. Dose-intense cyclophosphamide/etoposide has promising efficacy; however, nonhematologic toxicity can be considerable. The better tolerance, high response rate, and encouraging 2-year survival of this regimen in combination with further dose-dense consolidation in patients with high-risk NHL are encouraging.

Full Text

Duke Authors

Cited Authors

  • Talbot, J; Ibom, VK; Rizzieri, DA; Barrier, R; Niedzwieki, D; DeCastro, CM; Moore, JO; Buckley, P; Laney, R; Stevenson, D; Rumbaugh, H; Gockerman, JP

Published Date

  • September 2004

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 116 - 122

PubMed ID

  • 15453927

International Standard Serial Number (ISSN)

  • 1526-9655

Digital Object Identifier (DOI)

  • 10.3816/clm.2004.n.018


  • eng

Conference Location

  • United States