Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen.

Published

Journal Article

Reduction in the toxicity of allogeneic transplantation with nonmyeloablative induction regimens has expanded the scope of practice to older and more debilitated patients. However, the limited availability of matched sibling donors requires that alternative donor sources be investigated. Reported here are 2 cases of patients with advanced hematologic malignancies without matched siblings, partially matched family members, or matched unrelated donors who successfully underwent nonmyeloablative conditioning therapy followed by infusion of partially matched, unrelated-donor cord blood cells. The patients are in remission and remain 100% donor as assessed by short tandem repeat analysis of the marrow 6 and 12 months following transplantation.

Full Text

Duke Authors

Cited Authors

  • Rizzieri, DA; Long, GD; Vredenburgh, JJ; Gasparetto, C; Morris, A; Stenzel, TT; Davis, P; Chao, NJ

Published Date

  • December 2001

Published In

Volume / Issue

  • 98 / 12

Start / End Page

  • 3486 - 3488

PubMed ID

  • 11719394

Pubmed Central ID

  • 11719394

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

International Standard Serial Number (ISSN)

  • 0006-4971

Digital Object Identifier (DOI)

  • 10.1182/blood.v98.12.3486

Language

  • eng