Combination chemotherapy in histiocytosis X.

Journal Article (Journal Article)

Twenty-five children with generalized histiocytosis X were treated with a combination of cyclophosphamide, vinblastine, and prednisone: 8 patients experienced complete response, 8 partial response, 2 imporvement, and 7 no response. Response rates for children over 1 year of age were higher than those reported for single agents. Twelve children are now off therapy with no evidence of disease for 10--50 months. Very poor response rates and high toxicity were seen in children less than 1 year of age. The two infants who eventually achieved CR did so by other therapies. Further trials in combination chemotherapy must weight possible long-term effects of such therapy against the prospect of more rapid disease control.

Full Text

Duke Authors

Cited Authors

  • Komp, DM; Vietti, TJ; Berry, DH; Starling, KA; Haggard, ME; George, SL

Published Date

  • 1977

Published In

Volume / Issue

  • 3 / 3

Start / End Page

  • 267 - 273

PubMed ID

  • 311409

International Standard Serial Number (ISSN)

  • 0098-1532

Digital Object Identifier (DOI)

  • 10.1002/mpo.2950030308


  • eng

Conference Location

  • United States