Ha-ras polymorphisms in epithelial ovarian cancer.

Journal Article (Journal Article)

Unusual restriction fragment length polymorphisms (RFLPs) of the Ha-ras locus have been found in DNA from leukocytes and tumor tissue of cancer patients. To determine whether rare alleles would be observed frequently in patients with ovarian cancer, Ha-ras RFLPs were studied in DNA from 42 different ovarian epithelial tumors and from the peripheral blood leukocytes of 76 normal individuals. Four common, seven intermediate, and seven rare alleles were detected overall. Similar fractions of rare alleles were found in DNA from ovarian cancers and from the peripheral blood of normal individuals. Thus, the frequency of unusual Ha-ras RFLPs did not distinguish patients with ovarian cancers from apparently healthy individuals.

Full Text

Duke Authors

Cited Authors

  • O'Briant, K; Chrysson, N; Hunter, V; Tyson, F; Tanner, M; Daly, L; George, SL; Berchuck, A; Soper, J; Fowler, W

Published Date

  • June 1992

Published In

Volume / Issue

  • 45 / 3

Start / End Page

  • 299 - 302

PubMed ID

  • 1351862

Pubmed Central ID

  • 1351862

International Standard Serial Number (ISSN)

  • 0090-8258

Digital Object Identifier (DOI)

  • 10.1016/0090-8258(92)90308-6


  • eng

Conference Location

  • United States