Strength of accumulating evidence and data monitoring committee decision making.
Publication
, Journal Article
George, SL; Freidlin, B; Korn, EL
Published in: Stat Med
September 15, 2004
The data monitoring committee (DMC) is a vital component of a randomized clinical trial. Its responsibilities include stopping the trial early for extreme results. The decision to stop the trial must be based on a careful synthesis of statistical methodology and clinical judgment. It is critical to ensure the validity of this complex process. In this paper we present results of a survey of 21 DMC members conducted to investigate how they evaluate accumulating evidence. The results indicate that some DMC members may be over-interpreting developing trends in the data.
Duke Scholars
Published In
Stat Med
DOI
ISSN
0277-6715
Publication Date
September 15, 2004
Volume
23
Issue
17
Start / End Page
2659 / 2672
Location
England
Related Subject Headings
- Survival Analysis
- Surveys and Questionnaires
- Statistics & Probability
- Randomized Controlled Trials as Topic
- Neoplasms
- Humans
- Decision Making
- Data Interpretation, Statistical
- Clinical Trials Data Monitoring Committees
- Antineoplastic Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
George, S. L., Freidlin, B., & Korn, E. L. (2004). Strength of accumulating evidence and data monitoring committee decision making. Stat Med, 23(17), 2659–2672. https://doi.org/10.1002/sim.1859
George, Stephen L., Boris Freidlin, and Edward L. Korn. “Strength of accumulating evidence and data monitoring committee decision making.” Stat Med 23, no. 17 (September 15, 2004): 2659–72. https://doi.org/10.1002/sim.1859.
George SL, Freidlin B, Korn EL. Strength of accumulating evidence and data monitoring committee decision making. Stat Med. 2004 Sep 15;23(17):2659–72.
George, Stephen L., et al. “Strength of accumulating evidence and data monitoring committee decision making.” Stat Med, vol. 23, no. 17, Sept. 2004, pp. 2659–72. Pubmed, doi:10.1002/sim.1859.
George SL, Freidlin B, Korn EL. Strength of accumulating evidence and data monitoring committee decision making. Stat Med. 2004 Sep 15;23(17):2659–2672.
Published In
Stat Med
DOI
ISSN
0277-6715
Publication Date
September 15, 2004
Volume
23
Issue
17
Start / End Page
2659 / 2672
Location
England
Related Subject Headings
- Survival Analysis
- Surveys and Questionnaires
- Statistics & Probability
- Randomized Controlled Trials as Topic
- Neoplasms
- Humans
- Decision Making
- Data Interpretation, Statistical
- Clinical Trials Data Monitoring Committees
- Antineoplastic Agents