Strength of accumulating evidence and data monitoring committee decision making.

Journal Article (Journal Article)

The data monitoring committee (DMC) is a vital component of a randomized clinical trial. Its responsibilities include stopping the trial early for extreme results. The decision to stop the trial must be based on a careful synthesis of statistical methodology and clinical judgment. It is critical to ensure the validity of this complex process. In this paper we present results of a survey of 21 DMC members conducted to investigate how they evaluate accumulating evidence. The results indicate that some DMC members may be over-interpreting developing trends in the data.

Full Text

Duke Authors

Cited Authors

  • George, SL; Freidlin, B; Korn, EL

Published Date

  • September 15, 2004

Published In

Volume / Issue

  • 23 / 17

Start / End Page

  • 2659 - 2672

PubMed ID

  • 15316949

International Standard Serial Number (ISSN)

  • 0277-6715

Digital Object Identifier (DOI)

  • 10.1002/sim.1859


  • eng

Conference Location

  • England