Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.

Published

Journal Article

The retroviral transmembrane envelope protein p15E is immunosuppressive in that it inhibits immune responses of lymphocytes, monocytes, and macrophages. A region of p15E has been conserved among murine and feline retroviruses; a homologous region is also found in the transmembrane envelope proteins of the human retroviruses HTLV-I and HTLV-II and in a putative envelope protein encoded by an endogenous C-type human retroviral DNA. A peptide (CKS-17) was synthesized to correspond to this region of homology and was examined for its effects on lymphocyte proliferation. CKS-17 inhibited the proliferation of an interleukin-2-dependent murine cytotoxic T-cell line as well as alloantigen-stimulated proliferation of murine and human lymphocytes. Four other peptides, representing different regions of virus proteins, were inactive. These results suggest that the immunosuppressive portion of retroviral transmembrane envelope proteins may reside, at least in part, in a-conserved sequence represented by the CKS-17 peptide.

Full Text

Duke Authors

Cited Authors

  • Cianciolo, GJ; Copeland, TD; Oroszlan, S; Snyderman, R

Published Date

  • October 25, 1985

Published In

Volume / Issue

  • 230 / 4724

Start / End Page

  • 453 - 455

PubMed ID

  • 2996136

Pubmed Central ID

  • 2996136

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2996136

Language

  • eng

Conference Location

  • United States