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Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.

Publication ,  Journal Article
Cianciolo, GJ; Copeland, TD; Oroszlan, S; Snyderman, R
Published in: Science
October 25, 1985

The retroviral transmembrane envelope protein p15E is immunosuppressive in that it inhibits immune responses of lymphocytes, monocytes, and macrophages. A region of p15E has been conserved among murine and feline retroviruses; a homologous region is also found in the transmembrane envelope proteins of the human retroviruses HTLV-I and HTLV-II and in a putative envelope protein encoded by an endogenous C-type human retroviral DNA. A peptide (CKS-17) was synthesized to correspond to this region of homology and was examined for its effects on lymphocyte proliferation. CKS-17 inhibited the proliferation of an interleukin-2-dependent murine cytotoxic T-cell line as well as alloantigen-stimulated proliferation of murine and human lymphocytes. Four other peptides, representing different regions of virus proteins, were inactive. These results suggest that the immunosuppressive portion of retroviral transmembrane envelope proteins may reside, at least in part, in a-conserved sequence represented by the CKS-17 peptide.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

October 25, 1985

Volume

230

Issue

4724

Start / End Page

453 / 455

Location

United States

Related Subject Headings

  • Viral Envelope Proteins
  • Spleen
  • Retroviridae
  • Peptides
  • Mice, Inbred BALB C
  • Mice
  • Lymphocytes
  • Lymphocyte Culture Test, Mixed
  • Lymphocyte Activation
  • Leukemia Virus, Murine
 

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Cianciolo, G. J., Copeland, T. D., Oroszlan, S., & Snyderman, R. (1985). Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science, 230(4724), 453–455. https://doi.org/10.1126/science.2996136
Cianciolo, G. J., T. D. Copeland, S. Oroszlan, and R. Snyderman. “Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.Science 230, no. 4724 (October 25, 1985): 453–55. https://doi.org/10.1126/science.2996136.
Cianciolo GJ, Copeland TD, Oroszlan S, Snyderman R. Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science. 1985 Oct 25;230(4724):453–5.
Cianciolo, G. J., et al. “Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.Science, vol. 230, no. 4724, Oct. 1985, pp. 453–55. Pubmed, doi:10.1126/science.2996136.
Cianciolo GJ, Copeland TD, Oroszlan S, Snyderman R. Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science. 1985 Oct 25;230(4724):453–455.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

October 25, 1985

Volume

230

Issue

4724

Start / End Page

453 / 455

Location

United States

Related Subject Headings

  • Viral Envelope Proteins
  • Spleen
  • Retroviridae
  • Peptides
  • Mice, Inbred BALB C
  • Mice
  • Lymphocytes
  • Lymphocyte Culture Test, Mixed
  • Lymphocyte Activation
  • Leukemia Virus, Murine