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Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas.

Publication ,  Journal Article
Cianciolo, GJ; Herberman, RB; Snyderman, R
Published in: J Natl Cancer Inst
October 1980

Extracts prepared from spontaneous mouse mammary adenocarcinomas, as well as plasma and urine from inbred C3H/HeN mice carrying murine mammary tumor virus and bearing such tumors, significantly inhibited the accumulation of macrophages at inflammatory sites in inbred the accumulation of macrophages at inflammatory sites in inbred C3Heb/FeJ mice. Much of the inhibitory activity from tumor cells was associated with products having a molecular weight (¿ 30,000); the inhibitory factor isolated from the plasma and urine of tumor-bearing animals had a molecular weight of 30,000 or less. Liver and spleen tissue, plasma, and urine from non-tumor-bearing animals had a molecular weight of 30,000 or less. Liver and spleen tissue, plasma, and urine from non-tumor-bearing animals had no effect on macrophage accumulation. Tumor cell extracts, plasma, and urine from tumor-bearing mice were shown to be free of infectious lactate dehydrogenase virus, a frequent contaminant of transplanted tumor and a known modifier of macrophage function. These results agreed with earlier reports of inhibitory activity for macrophage accumulation found in the tumors and sera of mice bearing multiple-passaged transplanted tumors and suggested that spontaneously arising neoplasms may subvert immune surveillance by depressing the ability of macrophages to respond to inflammatory stimuli.

Duke Scholars

Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

October 1980

Volume

65

Issue

4

Start / End Page

829 / 834

Location

United States

Related Subject Headings

  • Tumor Virus Infections
  • Oncology & Carcinogenesis
  • Molecular Weight
  • Mice, Inbred C3H
  • Mice
  • Mammary Neoplasms, Experimental
  • Male
  • Macrophages
  • Injections, Subcutaneous
  • Inflammation
 

Citation

APA
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ICMJE
MLA
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Cianciolo, G. J., Herberman, R. B., & Snyderman, R. (1980). Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas. J Natl Cancer Inst, 65(4), 829–834. https://doi.org/10.1093/jnci/65.4.829
Cianciolo, G. J., R. B. Herberman, and R. Snyderman. “Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas.J Natl Cancer Inst 65, no. 4 (October 1980): 829–34. https://doi.org/10.1093/jnci/65.4.829.
Cianciolo GJ, Herberman RB, Snyderman R. Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas. J Natl Cancer Inst. 1980 Oct;65(4):829–34.
Cianciolo, G. J., et al. “Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas.J Natl Cancer Inst, vol. 65, no. 4, Oct. 1980, pp. 829–34. Pubmed, doi:10.1093/jnci/65.4.829.
Cianciolo GJ, Herberman RB, Snyderman R. Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas. J Natl Cancer Inst. 1980 Oct;65(4):829–834.
Journal cover image

Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

October 1980

Volume

65

Issue

4

Start / End Page

829 / 834

Location

United States

Related Subject Headings

  • Tumor Virus Infections
  • Oncology & Carcinogenesis
  • Molecular Weight
  • Mice, Inbred C3H
  • Mice
  • Mammary Neoplasms, Experimental
  • Male
  • Macrophages
  • Injections, Subcutaneous
  • Inflammation