Statistical consideration of adaptive methods in clinical development.

Published

Journal Article

In recent years, the use of adaptive methods in clinical development based on accrued data has become very popular due to its flexibility in modifying trial procedures and/or statistical procedures of on-going clinical trials. However, it is a concern that the actual patient population after the modifications could deviate from the originally targeted patient population. Major modifications of trial procedures and/or statistical procedures of on-going trials may result in a totally different trial, which is unable to address the scientific/medical questions that the trial intends to answer.

Full Text

Duke Authors

Cited Authors

  • Chow, S-C; Chang, M; Pong, A

Published Date

  • 2005

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 575 - 591

PubMed ID

  • 16022164

Pubmed Central ID

  • 16022164

International Standard Serial Number (ISSN)

  • 1054-3406

Digital Object Identifier (DOI)

  • 10.1081/BIP-200062277

Language

  • eng

Conference Location

  • England