Statistical consideration of adaptive methods in clinical development.
Journal Article (Journal Article)
In recent years, the use of adaptive methods in clinical development based on accrued data has become very popular due to its flexibility in modifying trial procedures and/or statistical procedures of on-going clinical trials. However, it is a concern that the actual patient population after the modifications could deviate from the originally targeted patient population. Major modifications of trial procedures and/or statistical procedures of on-going trials may result in a totally different trial, which is unable to address the scientific/medical questions that the trial intends to answer.
Full Text
Duke Authors
Cited Authors
- Chow, S-C; Chang, M; Pong, A
Published Date
- 2005
Published In
Volume / Issue
- 15 / 4
Start / End Page
- 575 - 591
PubMed ID
- 16022164
International Standard Serial Number (ISSN)
- 1054-3406
Digital Object Identifier (DOI)
- 10.1081/BIP-200062277
Language
- eng
Conference Location
- England