Analysis of clinical data with breached blindness.

Journal Article (Journal Article)

In clinical trials, blinding is usually employed to prevent bias that may be introduced due to the knowledge of the identity of the treatment codes. This bias could alter the conclusion of statistical inference on the treatment effect. The purpose of this article is to propose a method for analysing clinical data with breached blindness. The example regarding the study of the effectiveness of an appetite suppressant in weight loss in obese woman as described in Brownell and Stunkard (Am. J. Psychiatry 1982; 139:1487-1489) is used to illustrate the application of the proposed methods.

Full Text

Duke Authors

Cited Authors

  • Chow, S-C; Shao, J

Published Date

  • April 30, 2004

Published In

Volume / Issue

  • 23 / 8

Start / End Page

  • 1185 - 1193

PubMed ID

  • 15083477

International Standard Serial Number (ISSN)

  • 0277-6715

Digital Object Identifier (DOI)

  • 10.1002/sim.1694


  • eng

Conference Location

  • England