Immunosenescence and germinal center reaction.
Publication
, Journal Article
Zheng, B; Han, S; Takahashi, Y; Kelsoe, G
Published in: Immunol Rev
December 1997
Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation of immunocytes with reduced function and accumulation of lymphocyte clones with self-reactive potential. Coincidently, there is a profound reduction of the germinal center reaction in the aged. While this reduction is likely the result of age-associated impairment in lymphocyte function (e.g. diminished response to costimulus, altered lymphokine production etc.), the reduction of germinal centers may itself make an important contribution to further immunological dysfunction.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Immunol Rev
DOI
ISSN
0105-2896
Publication Date
December 1997
Volume
160
Start / End Page
63 / 77
Location
England
Related Subject Headings
- Time Factors
- Mutation
- Mice
- Immunology
- Humans
- Germinal Center
- Bone Marrow
- Antibody Formation
- Animals
- Aging
Citation
APA
Chicago
ICMJE
MLA
NLM
Zheng, B., Han, S., Takahashi, Y., & Kelsoe, G. (1997). Immunosenescence and germinal center reaction. Immunol Rev, 160, 63–77. https://doi.org/10.1111/j.1600-065x.1997.tb01028.x
Zheng, B., S. Han, Y. Takahashi, and G. Kelsoe. “Immunosenescence and germinal center reaction.” Immunol Rev 160 (December 1997): 63–77. https://doi.org/10.1111/j.1600-065x.1997.tb01028.x.
Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev. 1997 Dec;160:63–77.
Zheng, B., et al. “Immunosenescence and germinal center reaction.” Immunol Rev, vol. 160, Dec. 1997, pp. 63–77. Pubmed, doi:10.1111/j.1600-065x.1997.tb01028.x.
Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev. 1997 Dec;160:63–77.
Published In
Immunol Rev
DOI
ISSN
0105-2896
Publication Date
December 1997
Volume
160
Start / End Page
63 / 77
Location
England
Related Subject Headings
- Time Factors
- Mutation
- Mice
- Immunology
- Humans
- Germinal Center
- Bone Marrow
- Antibody Formation
- Animals
- Aging