Immunosenescence and germinal center reaction.

Journal Article (Journal Article;Review)

Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation of immunocytes with reduced function and accumulation of lymphocyte clones with self-reactive potential. Coincidently, there is a profound reduction of the germinal center reaction in the aged. While this reduction is likely the result of age-associated impairment in lymphocyte function (e.g. diminished response to costimulus, altered lymphokine production etc.), the reduction of germinal centers may itself make an important contribution to further immunological dysfunction.

Full Text

Duke Authors

Cited Authors

  • Zheng, B; Han, S; Takahashi, Y; Kelsoe, G

Published Date

  • December 1997

Published In

Volume / Issue

  • 160 /

Start / End Page

  • 63 - 77

PubMed ID

  • 9476666

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1111/j.1600-065x.1997.tb01028.x


  • eng

Conference Location

  • England