Sites of B-cell activation in vivo.

Journal Article (Journal Article;Review)

Novel techniques have made possible in situ analyses of the lymphocyte populations responding to antigen. In the spleen, antigen-specific T and B cells are first observed in the periarteriolar lymphoid sheath. Following conjugate formation between specific T and B lymphocytes, B-cell proliferation and differentiation takes place in two distinct sites, the periarteriolar lymphoid sheath-associated foci and germinal centers.

Full Text

Duke Authors

Cited Authors

  • Kelsoe, G; Zheng, B

Published Date

  • June 1993

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 418 - 422

PubMed ID

  • 8347301

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/0952-7915(93)90062-w


  • eng

Conference Location

  • England