Sites of B-cell activation in vivo.
Journal Article (Review)
Novel techniques have made possible in situ analyses of the lymphocyte populations responding to antigen. In the spleen, antigen-specific T and B cells are first observed in the periarteriolar lymphoid sheath. Following conjugate formation between specific T and B lymphocytes, B-cell proliferation and differentiation takes place in two distinct sites, the periarteriolar lymphoid sheath-associated foci and germinal centers.
Full Text
Duke Authors
Cited Authors
- Kelsoe, G; Zheng, B
Published Date
- June 1993
Published In
Volume / Issue
- 5 / 3
Start / End Page
- 418 - 422
PubMed ID
- 8347301
International Standard Serial Number (ISSN)
- 0952-7915
Language
- eng
Conference Location
- England