Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells.

Journal Article

BACKGROUND: gamma delta T cells, like alpha beta T cells, are components of all well-studied vertebrate immune systems. Yet, the contribution of gamma delta T cells to immune responses is poorly characterized. In particular, it has not been resolved whether gamma delta cells, independent of any other T cells, can help B cells produce immunoglobulin and form germinal centers, anatomical foci of specialized T cell-B cell collaboration. RESULTS: TCR beta-/- mice, which lack all T cells except gamma delta T cells, routinely displayed higher levels of antibody than fully T cell-deficient mice. Repeated parasitic infection of TCR beta-/- mice, but not of T cell-deficient mice, increased antibody levels and induced germinal centers that contained B cells and monoclonal gamma delta cells in close juxtaposition. However, antibody specificities were more commonly against self than against the challenging pathogen. gamma delta T cell-B cell help was not induced by repeated inoculation of TCR beta-/- mice with mycobacterial antigens. CONCLUSIONS: In the absence of any other T cells, gamma delta T cell-B cell collaboration can be significantly enhanced by repeated infection. However, the lack of obvious enrichment for antibodies against the challenging pathogen distinguishes gamma delta T cell help from alpha beta T cell help induced under analogous circumstances. The increased production of generalized antibodies may be particularly relevant to the development of autoimmunity, which commonly occurs in patients suffering from alpha beta T cell deficiencies, such as AIDS.

Full Text

Duke Authors

Cited Authors

  • Pao, W; Wen, L; Smith, AL; Gulbranson-Judge, A; Zheng, B; Kelsoe, G; MacLennan, IC; Owen, MJ; Hayday, AC

Published Date

  • October 1, 1996

Published In

Volume / Issue

  • 6 / 10

Start / End Page

  • 1317 - 1325

PubMed ID

  • 8939571

International Standard Serial Number (ISSN)

  • 0960-9822

Language

  • eng

Conference Location

  • England