Therapeutic CD154 antibody for lupus: promise for the future?


Journal Article

Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease characterized by the production of pathogenic autoantibodies. A new study demonstrates that passive antibody specific for the TNF family member, CD154, ameliorates disease by reducing levels of self-reactive antibody in the serum. This study demonstrates a substantial potential for anti-CD154 antibody in the treatment of humoral autoimmunity.

Full Text

Duke Authors

Cited Authors

  • Kelsoe, G

Published Date

  • November 2003

Published In

Volume / Issue

  • 112 / 10

Start / End Page

  • 1480 - 1482

PubMed ID

  • 14617748

Pubmed Central ID

  • 14617748

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI20371


  • eng

Conference Location

  • United States