Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody.

Journal Article

Preinjection of C57BL/6 mice with nano-to microgram amounts of a monoclonal IgG1 antibody directed against a binding site-related idiotope of the anti-NP [(4-hydroxy-3-nitro-phenyl)acetyl] antibody B1-8 results in enhancement or suppression of the corresponding and of another B1-8 idiotope in a subsequent anti-NP response, depending on the dose of the injected anti-idiotope antibody. The enhancing and suppressive effects appear two weeks after anti-idiotope administration and are maximal after 6-8 weeks. They are predominantly expressed at the level of IgG, not IgM, antibodies. Enhancement of idiotype expression, i.e. idiotypic memory, can also be induced by the injection of idiotypic antibody of the IgM class, namely antibody B1-8. This effect might represent one of the general mechanisms by which immunological memory is established.

Full Text

Duke Authors

Cited Authors

  • Kelsoe, G; Reth, M; Rajewsky, K

Published Date

  • May 1, 1981

Published In

Volume / Issue

  • 11 / 5

Start / End Page

  • 418 - 423

PubMed ID

  • 6790289

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.1830110513

Language

  • eng

Conference Location

  • Germany