Murine V kappa gene expression does not follow the VH paradigm.

Journal Article (Journal Article)

V kappa gene family expression among LPS-reactive murine B lymphocytes, unlike that of VH gene families, is not proportional to genomic complexity, i.e., nonstoichiometric. Furthermore, no positional bias for the overexpression of J-proximal V kappa genes (V kappa 21) is observed among neonatal B lymphocytes. Yet, the V kappa 1 and V kappa 9 families located in the center of V kappa locus are preferentially used by neonatal B splenocytes. Thus, the mechanisms of V kappa gene rearrangement and expression appear to differ significantly from those controlling the VH locus.

Full Text

Duke Authors

Cited Authors

  • Kaushik, A; Schulze, DH; Bona, C; Kelsoe, G

Published Date

  • May 1, 1989

Published In

Volume / Issue

  • 169 / 5

Start / End Page

  • 1859 - 1864

PubMed ID

  • 2497227

Pubmed Central ID

  • PMC2189305

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.169.5.1859


  • eng

Conference Location

  • United States