Antibody response to a T-dependent antigen requires B cell expression of complement receptors.

Published

Journal Article

Several lines of evidence indicate that antibody responses to T-dependent antigens require complement receptors expressed on either B lymphocytes or follicular dendritic cells. We have used RAG-2 deficient blastocyst complementation to create mice specifically lacking B cell complement receptors. Despite normal expression of complement receptor 1 (CR1[CD35]) and CR2 (CD21) on follicular dendritic cells, these mice have a profound defect in their capacity to mount a T-dependent antibody response. This is the first direct demonstration in vivo that B cell expression of complement receptors is required for a humoral immune response. This is the first direct demonstration in vivo that B cell expression of complement receptors is required for a humoral immune response. This suggests that CD21 and/or CD35 on B lymphocytes may be required for cellular activation, adsorptive endocytosis of antigen, recruitment to germinal centers, and/or protection from apoptosis during the humoral response to T-dependent antigens.

Full Text

Duke Authors

Cited Authors

  • Croix, DA; Ahearn, JM; Rosengard, AM; Han, S; Kelsoe, G; Ma, M; Carroll, MC

Published Date

  • April 1, 1996

Published In

Volume / Issue

  • 183 / 4

Start / End Page

  • 1857 - 1864

PubMed ID

  • 8666942

Pubmed Central ID

  • 8666942

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.183.4.1857

Language

  • eng

Conference Location

  • United States