T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.

Journal Article

After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a single white pulp region. These migrants constitute a unique set of T helper cells that express antigen-specific alpha beta TCR, CD3, and CD4, but little or no Thy-1, a differentiation antigen present on the great majority of peripheral murine T lymphocytes. The origin of CD4+ Thy-1 follicular T cells appears to be the Thy+ population in the PALS, as both sets commonly share identical V(D)J rearrangements.

Full Text

Duke Authors

Cited Authors

  • Zheng, B; Han, S; Kelsoe, G

Published Date

  • September 1, 1996

Published In

Volume / Issue

  • 184 / 3

Start / End Page

  • 1083 - 1091

PubMed ID

  • 9064325

International Standard Serial Number (ISSN)

  • 0022-1007

Language

  • eng

Conference Location

  • United States