Alternative pathways for the selection of antigen-specific peripheral T cells.

Published

Journal Article

In the thymus, maturing lymphocytes receive activation signals mediated by the T-cell antigen receptor (TCR) that either promote clonal survival (positive selection) or induce apoptosis (negative selection). This balance between life and death is mirrored by the sensitivity of cortical thymocytes to apoptotic death induced by antibodies against the CD3 component of the TCR signal-transduction complex, bacterial superantigens that bind to the TCR beta-chain, and corticosteroids. In contrast, mature peripheral T cells are positively activated by anti-CD3 antibody or superantigens and are resistant to steroid-induced death. Here we show that in splenic germinal centres, T cells regain thymocyte-like sensitivity to TCR- and steroid-induced apoptosis and undergo antigen-driven positive and negative selection. T-cell responses elsewhere in the spleen are unaccompanied by programmed cell death. Our observations define a new differentiation pathway for peripheral T cells and suggest that germinal centres induce a lymphocyte phenotype necessary for the maintenance of self-tolerance.

Full Text

Duke Authors

Cited Authors

  • Zheng, B; Han, S; Zhu, Q; Goldsby, R; Kelsoe, G

Published Date

  • November 21, 1996

Published In

Volume / Issue

  • 384 / 6606

Start / End Page

  • 263 - 266

PubMed ID

  • 8918876

Pubmed Central ID

  • 8918876

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/384263a0

Language

  • eng

Conference Location

  • England