T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells.
Published
Journal Article
Inflammation elicits a splenic lymphopoiesis of unknown physiologic significance but one that juxtaposes developing B cells and exogenous Ag. We show that immature and transitional 1 (immature/T1) B cells constitutively express activation-induced cytidine deaminase and B lymphocyte-induced maturation protein 1 in amounts that support accelerated plasmacytic differentiation and limited class-switch recombination. In vivo, activation of immature/T1 B cells by TLR ligands or bacterial vaccine rapidly induces T1 cells to divide, proliferate, and secrete IgM, IgG, or IgA Ab; in vitro, proliferation and differentiation are substantially enhanced by B cell-activating factor. We propose that inflammation-induced extramedullary lymphopoiesis represents a specialized mechanism for innate Ab responses to microbial pathogens.
Full Text
Duke Authors
Cited Authors
- Ueda, Y; Liao, D; Yang, K; Patel, A; Kelsoe, G
Published Date
- March 15, 2007
Published In
Volume / Issue
- 178 / 6
Start / End Page
- 3593 - 3601
PubMed ID
- 17339456
Pubmed Central ID
- 17339456
International Standard Serial Number (ISSN)
- 0022-1767
Digital Object Identifier (DOI)
- 10.4049/jimmunol.178.6.3593
Language
- eng
Conference Location
- United States