T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells.

Journal Article (Journal Article)

Inflammation elicits a splenic lymphopoiesis of unknown physiologic significance but one that juxtaposes developing B cells and exogenous Ag. We show that immature and transitional 1 (immature/T1) B cells constitutively express activation-induced cytidine deaminase and B lymphocyte-induced maturation protein 1 in amounts that support accelerated plasmacytic differentiation and limited class-switch recombination. In vivo, activation of immature/T1 B cells by TLR ligands or bacterial vaccine rapidly induces T1 cells to divide, proliferate, and secrete IgM, IgG, or IgA Ab; in vitro, proliferation and differentiation are substantially enhanced by B cell-activating factor. We propose that inflammation-induced extramedullary lymphopoiesis represents a specialized mechanism for innate Ab responses to microbial pathogens.

Full Text

Duke Authors

Cited Authors

  • Ueda, Y; Liao, D; Yang, K; Patel, A; Kelsoe, G

Published Date

  • March 15, 2007

Published In

Volume / Issue

  • 178 / 6

Start / End Page

  • 3593 - 3601

PubMed ID

  • 17339456

Pubmed Central ID

  • PMC1955467

International Standard Serial Number (ISSN)

  • 0022-1767

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.178.6.3593


  • eng

Conference Location

  • United States