Progression of impairment in patients with vascular cognitive impairment without dementia.


Journal Article

Little is known about progression, short of dementia, in vascular cognitive impairment. In the Canadian Study of Health and Aging, 149 participants (79.3 +/- 6.7 years; 61% women) were found to have vascular cognitive impairment, no dementia (CIND). After 5 years, 77 participants (52%) had died and 58 (46%) had developed dementia. Women were at greater risk of dementia (OR 2.1, 1.0 to 4.5). Of 32 participants alive without dementia, cognition had deteriorated in seven and improved in four. Half of those with vascular CIND developed dementia within 5 years, suggesting a target for preventive interventions.

Full Text

Duke Authors

Cited Authors

  • Wentzel, C; Rockwood, K; MacKnight, C; Hachinski, V; Hogan, DB; Feldman, H; Østbye, T; Wolfson, C; Gauthier, S; Verreault, R; McDowell, I

Published Date

  • August 28, 2001

Published In

Volume / Issue

  • 57 / 4

Start / End Page

  • 714 - 716

PubMed ID

  • 11524488

Pubmed Central ID

  • 11524488

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.57.4.714


  • eng

Conference Location

  • United States