Botulinum toxin therapy for neurologic disorders.

Journal Article (Journal Article;Review)

In the last 20 years, the therapeutic uses of botulinum toxin, a potent neurotoxin, have been investigated. The agent produces chemical denervation of muscle, thereby causing atrophy and weakness. Studies have shown that injection of this agent is an effective therapy for focal dystonias, particularly blepharospasm, hemifacial spasm, and torticollis. Investigation continues into the role of botulinum toxin in the treatment of anismus, detrusor-sphincter dyssynergia, writers' cramp, and other disorders in which focal weakening of selected muscles could be useful.

Full Text

Duke Authors

Cited Authors

  • Tim, R; Massey, JM

Published Date

  • May 1, 1992

Published In

Volume / Issue

  • 91 / 6

Start / End Page

  • 327 - 334

PubMed ID

  • 1579537

International Standard Serial Number (ISSN)

  • 0032-5481

Digital Object Identifier (DOI)

  • 10.1080/00325481.1992.11701332


  • eng

Conference Location

  • England