The treatment effectiveness project. A comparison of the effectiveness of paroxetine, problem-solving therapy, and placebo in the treatment of minor depression and dysthymia in primary care patients: background and research plan.

Published

Journal Article (Review)

This report describes the background, rationale, and research plan for a comparative treatment trial of the effectiveness of paroxetine, problem-solving therapy (PST-PC), and placebo in the treatment of minor depression and dysthymia in primary care patients. Patients were recruited from a variety of primary care practice settings in four separate geographic locations (Hanover, New Hampshire; Pittsburgh, Pennsylvania, San Antonio, Texas; and Seattle, Washington). Patients were randomly assigned to each of the three intervention conditions the medication/placebo conditions were double-blinded. The treatment trial was 11 weeks, with independent assessments of patient clinical status at baseline, 6 weeks, and 11 weeks. There was a follow-up at 25 weeks. Since there are relatively few placebo-controlled trials in primary care settings on patients with these disorders, the background of this project and a description of it are presented at this time, prior to the availability of outcome data, to provide methodological detail and to increase awareness in the research community of this treatment trial, with results to appear subsequently.

Full Text

Duke Authors

Cited Authors

  • Barrett, JE; Williams, JW; Oxman, TE; Katon, W; Frank, E; Hegel, MT; Sullivan, M; Schulberg, HC

Published Date

  • July 1999

Published In

Volume / Issue

  • 21 / 4

Start / End Page

  • 260 - 273

PubMed ID

  • 10514950

Pubmed Central ID

  • 10514950

Electronic International Standard Serial Number (EISSN)

  • 1873-7714

International Standard Serial Number (ISSN)

  • 0163-8343

Digital Object Identifier (DOI)

  • 10.1016/s0163-8343(99)00023-7

Language

  • eng