Absence of detectable pharmacological effects after oral administration of isoxsuprine.

Journal Article (Journal Article)

Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To define the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCl (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin temperatures, and cutaneous blood flow. The lack of pharmacological effect following oral administration was in sharp contrast to the marked response following i.v. dosing reported in earlier experiments.

Full Text

Duke Authors

Cited Authors

  • Harkins, JD; Mundy, GD; Stanley, S; Woods, WE; Sams, RA; Richardson, DR; Grambow, SC; Tobin, T

Published Date

  • July 1998

Published In

Volume / Issue

  • 30 / 4

Start / End Page

  • 294 - 299

PubMed ID

  • 9705111

International Standard Serial Number (ISSN)

  • 0425-1644

Digital Object Identifier (DOI)

  • 10.1111/j.2042-3306.1998.tb04100.x


  • eng

Conference Location

  • United States