Tumor-suppressor p53: implications for tumor development and prognosis.


Journal Article (Review)

The p53 protein plays a central role in modulating cellular responses to cytotoxic stresses by contributing to both cell-cycle arrest and programmed cell death. Loss of p53 function during tumorigenesis can lead to inappropriate cell growth, increased cell survival, and genetic instability. p53 gene mutations occur in approximately half of all malignancies from a wide range of human tumors. In some tumor types, these p53 mutations are associated with poor prognosis and treatment failure. Based on these insights, new approaches are being developed to prevent, diagnose, and treat cancer.

Full Text

Duke Authors

Cited Authors

  • Kirsch, DG; Kastan, MB

Published Date

  • September 1998

Published In

Volume / Issue

  • 16 / 9

Start / End Page

  • 3158 - 3168

PubMed ID

  • 9738588

Pubmed Central ID

  • 9738588

International Standard Serial Number (ISSN)

  • 0732-183X

Digital Object Identifier (DOI)

  • 10.1200/JCO.1998.16.9.3158


  • eng

Conference Location

  • United States