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Treatment and outcome of 82 patients with angiosarcoma.

Publication ,  Journal Article
Abraham, JA; Hornicek, FJ; Kaufman, AM; Harmon, DC; Springfield, DS; Raskin, KA; Mankin, HJ; Kirsch, DG; Rosenberg, AE; Nielsen, GP; Suit, HD ...
Published in: Ann Surg Oncol
June 2007

BACKGROUND: Angiosarcomas are an uncommon type of malignancy that are generally thought to behave usually in a locally aggressive fashion; they often metastasize to distant sites. METHODS: Patients with a diagnosis of angiosarcoma treated at our institution between 1980 and 2006 were analyzed for patient demographics, tumor characteristics, multimodality treatment, and outcomes. RESULTS: A total of 82 patients were divided into those with primary and advanced disease. Overall, the median age was 65 (range, 22-91) years, and 44% of patients were women. Median size of tumors was 3.8 cm, and 76% of tumors were intermediate or high grade. Tumors were located throughout the body: 32 cutaneous, 22 deep soft tissues or organs, 10 radiation or lymphedema field, 8 bone, and 7 nonirradiated breast. Of 46 patients with primary disease, all patients underwent surgical resection, 67% received radiotherapy, and 27% received chemotherapy. Five-year disease-specific survival was 60%, and negative prognostic factors included intermediate or high grade, and tumors arising in a radiated or lymphedema field. Of 36 patients with advanced disease, 36% underwent a palliative operation, 78% received radiation, and 58% received chemotherapy. Median survival was just 7.3 months, and cutaneous tumors predicted a better prognosis compared with other sites. CONCLUSIONS: Primary angiosarcomas treated with aggressive surgical resection and the addition of radiation for close margins or worrisome pathologic features can result in long-term survival in most patients. The role of adjuvant chemotherapy is unclear. Patients with advanced disease have a poor prognosis, but there can be dramatic responses to chemotherapy in a minority of patients.

Duke Scholars

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

June 2007

Volume

14

Issue

6

Start / End Page

1953 / 1967

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Soft Tissue Neoplasms
  • Skin Neoplasms
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Palliative Care
  • Oncology & Carcinogenesis
  • Neoplasms, Radiation-Induced
  • Neoplasm Staging
 

Citation

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Abraham, J. A., Hornicek, F. J., Kaufman, A. M., Harmon, D. C., Springfield, D. S., Raskin, K. A., … Yoon, S. S. (2007). Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol, 14(6), 1953–1967. https://doi.org/10.1245/s10434-006-9335-y
Abraham, John A., Francis J. Hornicek, Adam M. Kaufman, David C. Harmon, Dempsey S. Springfield, Kevin A. Raskin, Henry J. Mankin, et al. “Treatment and outcome of 82 patients with angiosarcoma.Ann Surg Oncol 14, no. 6 (June 2007): 1953–67. https://doi.org/10.1245/s10434-006-9335-y.
Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, et al. Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol. 2007 Jun;14(6):1953–67.
Abraham, John A., et al. “Treatment and outcome of 82 patients with angiosarcoma.Ann Surg Oncol, vol. 14, no. 6, June 2007, pp. 1953–67. Pubmed, doi:10.1245/s10434-006-9335-y.
Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS. Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol. 2007 Jun;14(6):1953–1967.
Journal cover image

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

June 2007

Volume

14

Issue

6

Start / End Page

1953 / 1967

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Soft Tissue Neoplasms
  • Skin Neoplasms
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Palliative Care
  • Oncology & Carcinogenesis
  • Neoplasms, Radiation-Induced
  • Neoplasm Staging