Future of early detection of lung cancer: the role of mouse models.

Journal Article (Journal Article;Review)

Early detection represents one of the most promising approaches to improving lung cancer survival. To date, no screening strategies have been shown to decrease mortality from the disease. Furthermore, no reliable circulating biomarkers of lung cancer have been identified that allow early diagnosis. With the advent of gene targeting technology, new genetically engineered mouse models of lung cancer closely recapitulate the pathobiology of human disease. These mouse models have enabled novel approaches to early detection, including the identification of cancer-associated serum markers using proteomic technologies and the development of new molecular imaging tools. The application of innovative technologies to accurate mouse models promises to accelerate the discovery of new molecular targets and imaging biomarkers for the early detection of lung cancer.

Full Text

Duke Authors

Cited Authors

  • Shaw, AT; Kirsch, DG; Jacks, T

Published Date

  • July 1, 2005

Published In

Volume / Issue

  • 11 / 13 Pt 2

Start / End Page

  • 4999s - 5003s

PubMed ID

  • 16000603

International Standard Serial Number (ISSN)

  • 1078-0432

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-05-9005


  • eng

Conference Location

  • United States