Genetic induction of tumorigenesis in swine.

Journal Article (Journal Article)

The transition from basic to clinical cancer research for a number of experimental therapeutics is hampered by the lack of a genetically malleable, large animal model. To this end, we genetically engineered primary porcine cells to be tumorigenic by expression of proteins known to perturb pathways commonly corrupted in human cancer. Akin to human cells, these porcine cells were quite resistant to transformation, requiring multiple genetic changes. Moreover, the transformed porcine cells produced tumors when returned to the isogenic host animal. The ability to now rapidly and reproducibly genetically induce tumors of sizes similar to those treated clinically in a large mammal similar to humans in many respects will provide a robust cancer model for preclinical studies dependent on generating large tumors.

Full Text

Duke Authors

Cited Authors

  • Adam, SJ; Rund, LA; Kuzmuk, KN; Zachary, JF; Schook, LB; Counter, CM

Published Date

  • February 15, 2007

Published In

Volume / Issue

  • 26 / 7

Start / End Page

  • 1038 - 1045

PubMed ID

  • 16964292

International Standard Serial Number (ISSN)

  • 0950-9232

Digital Object Identifier (DOI)

  • 10.1038/sj.onc.1209892


  • eng

Conference Location

  • England