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Genetically engineered human cancer models utilizing mammalian transgene expression.

Publication ,  Journal Article
Kendall, SD; Adam, SJ; Counter, CM
Published in: Cell Cycle
May 2006

Cancer models are vital to cancer biology research, and multiple cancer models are currently available that utilize either murine or human cells, each with particular strengths and weaknesses. The ability to transform primary human cells into tumors through the expression of specific transgenes offers many advantages as a cancer model, including genetic malleability and the ability to transform specific cell types. Until recently, the conversion of primary human cells into tumors through transgene expression required the use of viral genetic elements, which unfortunately adds uncertainty regarding which cancer pathways are affected and how they are affected. In recent years multiple reports have described the transformation of primary human cells into tumors using only mammalian transgenes. This review focuses on these five cancer models, comparing the different cell types which were transformed into tumors and which transgenes were expressed, as well as the cancer pathways affected in the disparate models. These genetically-engineered human cancer models offer a valuable tool to complement existing cancer models and further cancer research.

Duke Scholars

Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

May 2006

Volume

5

Issue

10

Start / End Page

1074 / 1079

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Tumor Suppressor Protein p53
  • Transgenes
  • Telomerase
  • Proto-Oncogene Proteins c-myc
  • Oncogene Protein p21(ras)
  • Mutation
  • Humans
  • Genetic Engineering
  • Gene Transfer Techniques
 

Citation

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Kendall, S. D., Adam, S. J., & Counter, C. M. (2006). Genetically engineered human cancer models utilizing mammalian transgene expression. Cell Cycle, 5(10), 1074–1079. https://doi.org/10.4161/cc.5.10.2734
Kendall, S DiSean, Stacey J. Adam, and Christopher M. Counter. “Genetically engineered human cancer models utilizing mammalian transgene expression.Cell Cycle 5, no. 10 (May 2006): 1074–79. https://doi.org/10.4161/cc.5.10.2734.
Kendall SD, Adam SJ, Counter CM. Genetically engineered human cancer models utilizing mammalian transgene expression. Cell Cycle. 2006 May;5(10):1074–9.
Kendall, S. DiSean, et al. “Genetically engineered human cancer models utilizing mammalian transgene expression.Cell Cycle, vol. 5, no. 10, May 2006, pp. 1074–79. Pubmed, doi:10.4161/cc.5.10.2734.
Kendall SD, Adam SJ, Counter CM. Genetically engineered human cancer models utilizing mammalian transgene expression. Cell Cycle. 2006 May;5(10):1074–1079.

Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

May 2006

Volume

5

Issue

10

Start / End Page

1074 / 1079

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Tumor Suppressor Protein p53
  • Transgenes
  • Telomerase
  • Proto-Oncogene Proteins c-myc
  • Oncogene Protein p21(ras)
  • Mutation
  • Humans
  • Genetic Engineering
  • Gene Transfer Techniques