Blood vessels engineered from human cells.
Journal Article (Journal Article)
Tissue engineering has made considerable progress in the past decade, but advances have stopped short of clinical application for most tissues. We postulated that an obstacle in engineering human tissues is the limited replicative capacity of adult somatic cells. To test this hypothesis, the effectiveness of telomerase expression to extend cellular lifespan was assessed in a model of human vascular tissue engineering. Telomerase expression in vascular cells isolated from elderly patients enabled the successful culture of engineered autologous blood vessels. Engineered vessels may one day provide a source of bypass conduit for patients with atherosclerotic disease.
- Poh, M; Boyer, M; Solan, A; Dahl, SLM; Pedrotty, D; Banik, SSR; McKee, JA; Klinger, RY; Counter, CM; Niklason, LE
- June 18, 2005
Volume / Issue
- 365 / 9477
Start / End Page
- 2122 - 2124
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)