Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids.
Publication
, Journal Article
Fumagalli, F; Jones, SR; Caron, MG; Seidler, FJ; Slotkin, TA
Published in: Brain Res
May 6, 1996
Serotonin transporter mRNA expression in midbrain of young and aged rats was measured after long-term infusion of dexamethasone (0.01 and 0.05 mg/kg/day). Aging alone had no effect. Dexamethasone significantly decreased expression in both young and old rats but the effect was greater in the aged group. Adrenocortical dysregulation is common in elderly depression; our results suggest that glucocorticoids interact with aging to exacerbate abnormalities of serotonergic function, contributing to reduced antidepressant effectiveness.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
May 6, 1996
Volume
719
Issue
1-2
Start / End Page
225 / 228
Location
Netherlands
Related Subject Headings
- Serotonin Plasma Membrane Transport Proteins
- Serotonin
- Rats, Sprague-Dawley
- Rats
- RNA, Messenger
- Neurology & Neurosurgery
- Nerve Tissue Proteins
- Membrane Transport Proteins
- Membrane Glycoproteins
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Fumagalli, F., Jones, S. R., Caron, M. G., Seidler, F. J., & Slotkin, T. A. (1996). Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids. Brain Res, 719(1–2), 225–228. https://doi.org/10.1016/0006-8993(96)00119-9
Fumagalli, F., S. R. Jones, M. G. Caron, F. J. Seidler, and T. A. Slotkin. “Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids.” Brain Res 719, no. 1–2 (May 6, 1996): 225–28. https://doi.org/10.1016/0006-8993(96)00119-9.
Fumagalli F, Jones SR, Caron MG, Seidler FJ, Slotkin TA. Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids. Brain Res. 1996 May 6;719(1–2):225–8.
Fumagalli, F., et al. “Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids.” Brain Res, vol. 719, no. 1–2, May 1996, pp. 225–28. Pubmed, doi:10.1016/0006-8993(96)00119-9.
Fumagalli F, Jones SR, Caron MG, Seidler FJ, Slotkin TA. Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids. Brain Res. 1996 May 6;719(1–2):225–228.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
May 6, 1996
Volume
719
Issue
1-2
Start / End Page
225 / 228
Location
Netherlands
Related Subject Headings
- Serotonin Plasma Membrane Transport Proteins
- Serotonin
- Rats, Sprague-Dawley
- Rats
- RNA, Messenger
- Neurology & Neurosurgery
- Nerve Tissue Proteins
- Membrane Transport Proteins
- Membrane Glycoproteins
- Male