Perinatal dietary exposure to soy lecithin: altered sensitivity to central cholinergic stimulation.

Journal Article (Journal Article)

The effects of perinatal exposure to soy lecithin preparation (SLP) on the development of cholinergic responses in the rat brain were examined by assessing the ability of intracisternally administered carbachol to stimulate 33Pi incorporation into phospholipids in vivo, an effect of carbachol mediated by muscarinic cholinergic receptors. Maternal intake of SLP produced a suppression of the cholinergic response in the offspring, an effect which was specific in that basal (unstimulated) incorporation rates were not reduced (in fact, they eventually became elevated), nor was the response to another neurotransmitter (dopamine) compromised. The effect occurred early in the preweanling stage, a period in which SLP exposure also enhances development of cholinergic nerve terminals. These results suggest that SLP exposure has a major effect on cholinergic synaptic development and reactivity, followed by secondary changes in other neurotransmitter pathways and by more generalized effects on basal membrane phospholipid turnover.

Full Text

Duke Authors

Cited Authors

  • Bell, JM; Whitmore, WL; Barnes, G; Seidler, FJ; Slotkin, TA

Published Date

  • 1986

Published In

Volume / Issue

  • 4 / 6

Start / End Page

  • 497 - 501

PubMed ID

  • 3455608

International Standard Serial Number (ISSN)

  • 0736-5748

Digital Object Identifier (DOI)

  • 10.1016/0736-5748(86)90001-8


  • eng

Conference Location

  • United States