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Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung.

Publication ,  Journal Article
Slotkin, TA; Pinkerton, KE; Seidler, FJ
Published in: Brain Res Dev Brain Res
November 30, 2000

Perinatal exposure to environmental tobacco smoke (ETS) is known to have adverse effects on respiratory function in conjunction with changes in autonomic responses. In the current study, Rhesus monkeys were exposed to ETS during late gestation and in the early neonatal period. Hearts and lungs were examined for changes in beta-adrenergic and m2-muscarinic cholinergic receptors, and for alterations in adenylyl cyclase activity. Whereas there were no changes in the heart, there was robust induction of adenylyl cyclase in the lung; previous work with prenatal nicotine exposure in rodent models has shown that adenylyl cyclase induction is associated with a shift towards predominance of cholinergic over adrenergic responses. These data indicate that perinatal ETS exposure evokes changes in cells signaling that they are selective for the lung and that may ultimately reflect adverse effects at the level of physiological function.

Duke Scholars

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

November 30, 2000

Volume

124

Issue

1-2

Start / End Page

53 / 58

Location

Netherlands

Related Subject Headings

  • Smoke
  • Receptors, Muscarinic
  • Receptors, Adrenergic, beta
  • Plants, Toxic
  • Nicotiana
  • Neurology & Neurosurgery
  • Myocardium
  • Macaca mulatta
  • Lung
  • Fetus
 

Citation

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Slotkin, T. A., Pinkerton, K. E., & Seidler, F. J. (2000). Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung. Brain Res Dev Brain Res, 124(1–2), 53–58. https://doi.org/10.1016/s0165-3806(00)00105-x
Slotkin, T. A., K. E. Pinkerton, and F. J. Seidler. “Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung.Brain Res Dev Brain Res 124, no. 1–2 (November 30, 2000): 53–58. https://doi.org/10.1016/s0165-3806(00)00105-x.
Slotkin, T. A., et al. “Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung.Brain Res Dev Brain Res, vol. 124, no. 1–2, Nov. 2000, pp. 53–58. Pubmed, doi:10.1016/s0165-3806(00)00105-x.
Journal cover image

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

November 30, 2000

Volume

124

Issue

1-2

Start / End Page

53 / 58

Location

Netherlands

Related Subject Headings

  • Smoke
  • Receptors, Muscarinic
  • Receptors, Adrenergic, beta
  • Plants, Toxic
  • Nicotiana
  • Neurology & Neurosurgery
  • Myocardium
  • Macaca mulatta
  • Lung
  • Fetus