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Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues.

Publication ,  Journal Article
Slotkin, TA; Navarro, HA; McCook, EC; Seidler, FJ
Published in: Life Sci
1990

Gestational exposure to nicotine has been shown to affect development of noradrenergic activity in both the central and peripheral nervous systems. In the current study, pregnant rats received nicotine infusions of 6 mg/kg/day throughout gestation, administered by osmotic minipump implants. After birth, offspring of the nicotine-infused dams exhibited marked increases in basal adenylate cyclase activity in membranes prepared from kidney and heart, as well as supersensitivity to stimulation by either a beta-adrenergic agonist, isoproterenol, or by forskolin. The altered responses were not accompanied by up-regulation of beta-adrenergic receptors: in fact, [125I]pindolol binding was significantly decreased in the nicotine group. These results indicate that fetal nicotine exposure affects enzymes involved in membrane receptor signal transduction, leading to altered responsiveness independently of changes at the receptor level.

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Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1990

Volume

47

Issue

17

Start / End Page

1561 / 1567

Location

Netherlands

Related Subject Headings

  • Up-Regulation
  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pindolol
  • Pharmacology & Pharmacy
  • Nicotine
  • Myocardium
 

Citation

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Slotkin, T. A., Navarro, H. A., McCook, E. C., & Seidler, F. J. (1990). Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues. Life Sci, 47(17), 1561–1567. https://doi.org/10.1016/0024-3205(90)90185-t
Slotkin, T. A., H. A. Navarro, E. C. McCook, and F. J. Seidler. “Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues.Life Sci 47, no. 17 (1990): 1561–67. https://doi.org/10.1016/0024-3205(90)90185-t.
Slotkin TA, Navarro HA, McCook EC, Seidler FJ. Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues. Life Sci. 1990;47(17):1561–7.
Slotkin, T. A., et al. “Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues.Life Sci, vol. 47, no. 17, 1990, pp. 1561–67. Pubmed, doi:10.1016/0024-3205(90)90185-t.
Slotkin TA, Navarro HA, McCook EC, Seidler FJ. Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues. Life Sci. 1990;47(17):1561–1567.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1990

Volume

47

Issue

17

Start / End Page

1561 / 1567

Location

Netherlands

Related Subject Headings

  • Up-Regulation
  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pindolol
  • Pharmacology & Pharmacy
  • Nicotine
  • Myocardium