Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues.

Published

Journal Article

Gestational exposure to nicotine has been shown to affect development of noradrenergic activity in both the central and peripheral nervous systems. In the current study, pregnant rats received nicotine infusions of 6 mg/kg/day throughout gestation, administered by osmotic minipump implants. After birth, offspring of the nicotine-infused dams exhibited marked increases in basal adenylate cyclase activity in membranes prepared from kidney and heart, as well as supersensitivity to stimulation by either a beta-adrenergic agonist, isoproterenol, or by forskolin. The altered responses were not accompanied by up-regulation of beta-adrenergic receptors: in fact, [125I]pindolol binding was significantly decreased in the nicotine group. These results indicate that fetal nicotine exposure affects enzymes involved in membrane receptor signal transduction, leading to altered responsiveness independently of changes at the receptor level.

Full Text

Duke Authors

Cited Authors

  • Slotkin, TA; Navarro, HA; McCook, EC; Seidler, FJ

Published Date

  • 1990

Published In

Volume / Issue

  • 47 / 17

Start / End Page

  • 1561 - 1567

PubMed ID

  • 2174490

Pubmed Central ID

  • 2174490

International Standard Serial Number (ISSN)

  • 0024-3205

Language

  • eng

Conference Location

  • Netherlands